| The history of the fine chemicals industry dates back | | | | Business segmentation 57 |
| to the late 18th century, when the early chemical | | | | R&D focus 58 |
| industry was evolved from natural dyes and | | | | Financial performance 60 |
| explosives into modern pharmaceutical products. | | | | Growth strategies 61 |
| However, by the end of the 19th century, the | | | | Increasing R&D activity in emerging markets 61 |
| commercial production of branded pharmaceuticals | | | | Microreactors: a new technology for pharmaceutical |
| flourished in Europe (especially in Germany, as many | | | | production 61 |
| of the active pharmaceutical ingredients were | | | | SWOT analysis 62 |
| produced in this country). | | | | Chapter 6 Sumitomo Chemical 64 |
| Fine chemicals are generally produced on a large | | | | Summary 64 |
| scale, which can be measured in thousands of tonnes | | | | Company overview 65 |
| per year for certain food additives and drug | | | | Business segmentation 65 |
| intermediates. Fine chemicals manufacturing is typically | | | | R&D focus 66 |
| carried out in batch processes, with synthesis being | | | | Financial performance 67 |
| followed by separation and purification steps. | | | | Growth strategies 69 |
| Pharmaceuticals has always been the largest market | | | | Strong progress in major R&D projects 69 |
| for the fine chemicals industry. Moreover, it is likely that | | | | Pursuing a new strategy of creative hybrid chemistry |
| pharmaceutical intermediates will account for over | | | | 69 |
| two-thirds of the fine chemicals market by 2012. | | | | Strong response to the EU's REACH legislation for |
| Although the number of fine chemicals companies | | | | chemicals 69 |
| involved in the manufacture of high potency APIs | | | | Creation of next-generation chemical safety |
| (HPAPIs) has historically been limited, the segment has | | | | information management database 70 |
| attracted more companies recently. | | | | SWOT analysis 71 |
| Profitability levels have fallen for many fine chemical | | | | Chapter 7 Merck KGaA Chemicals 74 |
| companies in recent years. However, the recent focus | | | | Summary 74 |
| on biopharmaceutical products holds promise for this | | | | Company overview 75 |
| industry in the future. For instance, many of the larger | | | | Business segmentation 75 |
| fine chemicals players have invested in biotechnology, | | | | R&D focus 76 |
| either through self-funded R&D programs or | | | | Financial performance 76 |
| through alliances and partnerships. | | | | Growth strategies 77 |
| Key features of this report | | | | Merck KGaA and Millipore partnership for specialty |
| • Overview of the global fine chemicals market | | | | products 77 |
| • Market dynamics and profitability of the global fine | | | | New pharmaceutical production plant to increase |
| chemicals market | | | | Merck KGaA's capacity in |
| • Detailed profiles of the leading 10 players in the | | | | Germany 78 |
| global fine chemicals market | | | | Stronger presence in India through acquisition of |
| • Key partnerships and M&A activities in the | | | | Bangalore Genei 78 |
| fine chemicals sector | | | | Merck Serono to build its R&D operations in China |
| • Key trends and opportunities in the global fine | | | | 78 |
| chemicals market | | | | SWOT analysis 79 |
| Scope of this report | | | | Chapter 8 Lanxess (Saltigo) 82 |
| • Develop insights into the global fine chemicals | | | | Summary 82 |
| market, including pharmaceutical intermediates, | | | | Company overview 83 |
| agrochemical intermediates, flavors and fragrances, | | | | Business segmentation 83 |
| dyes, and others | | | | R&D focus 84 |
| • Build knowledge of key partnerships and | | | | Financial performance 84 |
| M&A activities that are shaping the future of the | | | | Growth strategies 85 |
| global fine chemicals industry. | | | | Expansion in BRIC countries 85 |
| • Understand the major issues affecting the global | | | | Advanced Intermediates segment 86 |
| fine chemicals industry. | | | | Custom manufacturing 86 |
| • Assess the competitive landscape of the global | | | | SWOT analysis 87 |
| fine chemical industry. | | | | Chapter 9 Sigma-Aldrich 90 |
| Key Market Issues | | | | Summary 90 |
| • Increasing demand for HPAPIs: HPAPIs are very | | | | Company overview 91 |
| effective in treating diseases at low dosage; however, | | | | Business segmentation 91 |
| the production of such potent compounds requires | | | | R&D focus 92 |
| significant investment. Thus, many companies are also | | | | Financial performance 92 |
| differentiating their products from their competitors | | | | Growth strategies 93 |
| through specialized technologies and demonstrated | | | | Strong focus on emerging markets 93 |
| expertise. The growth in demand for HPAPIs, primarily | | | | Partnerships and alliances 94 |
| in cancer therapies, is expected to increase its sales in | | | | Targeting the high-growth biology segment 94 |
| the near future. Additionally, the ability to increase life | | | | SWOT analysis 95 |
| expectancy among cancer patients will also drive the | | | | Chapter 10 Jubilant Organosys 98 |
| demand for HPAPIs in coming years. | | | | Summary 98 |
| • Relocation to emerging and fast growing markets: | | | | Company overview 99 |
| Managing and rationalizing existing assets in the EU | | | | Business segmentation 100 |
| and investing in new facilities in emerging and fast | | | | R&D focus 101 |
| growing markets has been a key trend in the fine | | | | Financial performance 101 |
| chemicals sector recently. Growth in Western Europe | | | | Growth strategies 104 |
| started to slow in recent years, making Asia (mainly | | | | Integrated business model 104 |
| China and India) and Latin American countries the new | | | | Strong R&D and manufacturing services for |
| growth markets for the fine chemicals industry. | | | | intermediates and APIs 104 |
| • Advanced technologies: Recently, many of the | | | | Positioning as an outsourcing partner of choice 105 |
| leading pharmaceutical and fine chemicals | | | | SWOT analysis 106 |
| manufacturers have started to focus on small-scale | | | | Chapter 11 Johnson Matthey 108 |
| complex products, an area where advanced | | | | Summary 108 |
| technologies are required. For example, in June 2009, | | | | Company overview 109 |
| Italian fine chemicals company Endura announced that | | | | Business segmentation 109 |
| it would commercialize a technology that encapsulates | | | | R&D focus 110 |
| insecticide into very small crystals. The encapsulation | | | | Financial performance 111 |
| delays the release of insecticides, thus enabling an | | | | Growth strategies 112 |
| enzyme inhibitor to disable the enzymes that insects | | | | Johnson Matthey's Sustainability 2017 initiative 112 |
| use to block pesticides. Moreover, Endura will also | | | | Strong market position in APIs and contract |
| promote the concept of microencapsulated piperonyl | | | | manufacturing services 112 |
| butoxide (PBO, a naturally occurring synergist) in | | | | SWOT analysis 113 |
| agriculture throughout the world in collaboration with | | | | Chapter 12 Evonik Chemicals 116 |
| strategic partners. | | | | Summary 116 |
| Key findings from this report | | | | Company overview 117 |
| • The pharmaceutical industry has always been the | | | | Business segmentation 117 |
| largest market for the fine chemicals industry. Although | | | | R&D focus 117 |
| the number of fine chemicals companies that are | | | | Financial performance 118 |
| developing high-potency APIs has been limited, this | | | | Growth strategies 119 |
| segment has attracted many companies in recent | | | | Specialty chemicals remain a key focus area for |
| years. | | | | Evonik 119 |
| • Fine chemicals players with significant exposure to | | | | Strong commitment to custom manufacturing business |
| the generics segment are likely to face pressure on | | | | 120 |
| their profitability levels in the near future. However, the | | | | SWOT analysis 121 |
| recent shift in focus toward biopharmaceutical | | | | Chapter 13 Other major players 124 |
| products will expand the margin of this industry in | | | | Boehringer Ingelheim 124 |
| coming years. | | | | Company overview 124 |
| • Agrochemical intermediates represent the second | | | | Recent financial performance 124 |
| largest category among fine chemicals (after APIs), | | | | Divis Laboratories 125 |
| the majority of which are used in the manufacture of | | | | Company overview 125 |
| pesticides, herbicides, insecticides, fungicides, and | | | | Recent financial performance 126 |
| fumigates. | | | | Pfizer CentreSource 127 |
| • Outsourcing has become a key trend in this | | | | Company overview 127 |
| industry, fueled by the growing importance of | | | | Recent financial performance 127 |
| biopharmaceutical and virtual pharma companies in | | | | Cambrex 128 |
| low-cost destinations such as Asia. Outsourcing from | | | | Company overview 128 |
| biotech and pharmaceutical companies will strengthen | | | | Recent financial performance 128 |
| the custom manufacturing industry in India and China. | | | | Fabbrica Italiana Sintetici 129 |
| • BASF is one of the leading chemical producers in | | | | Company overview 129 |
| the world, with significant exposure in fine chemicals. | | | | Recent financial performance 130 |
| With a presence in over 80 countries, BASF is one of | | | | Appendix 131 |
| the leading suppliers of chemical intermediates to the | | | | Glossary 131 |
| plastic, automobile, agriculture, and pharmaceutical | | | | Index 133 |
| industries. | | | | List of Figures |
| Key questions answered | | | | Figure 2.1: Fine chemicals and their usage 27 |
| • What are the key trends of global fine chemicals | | | | Figure 3.2: BASF SWOT analysis 45 |
| industry? | | | | Figure 4.3: Lonza business divisions 49 |
| • Which are the leading players in the global fine | | | | Figure 4.4: Lonza SWOT analysis 54 |
| chemical market? | | | | Figure 5.5: DSM business focus 58 |
| • Which companies will drive the future of the global | | | | Figure 5.6: DSM SWOT analysis 62 |
| fine chemicals market? | | | | Figure 6.7: Sumitomo Chemical research laboratories |
| • What are the key strengths, weaknesses, threats, | | | | 67 |
| and opportunities for the leading fine chemicals | | | | Figure 6.8: Sumitomo Chemical SWOT analysis 71 |
| players? | | | | Figure 7.9: Merck KGaA Chemicals SWOT analysis 79 |
| • How has the financial performance of leading | | | | Figure 8.10: Saltigo SWOT analysis 87 |
| players in the global fine chemicals market faired | | | | Figure 9.11: Sigma-Aldrich SWOT analysis 95 |
| through the recent economic downturn? | | | | Figure 10.12: Jubilant Organosys business segmentation |
| • Which companies are best positioned to succeed | | | | 100 |
| in the global fine chemicals market during 2009–14? | | | | Figure 10.13: Jubilant Organosys SWOT analysis 106 |
| Table of Contents : | | | | Figure 11.14: Johnson Matthey business segmentation |
| The Top 10 Global Fine Chemicals Companies | | | | 109 |
| Executive summary 12 | | | | Figure 11.15: Johnson Matthey SWOT analysis 113 |
| Industry overview 12 | | | | Figure 12.16: Evonik Chemicals SWOT analysis 121 |
| BASF 13 | | | | List of Tables |
| Lonza 13 | | | | Table 2.1: Global fine chemicals market size, |
| DSM 14 | | | | 2009–2015 30 |
| Sumitomo Chemical 14 | | | | Table 2.2: Leading 10 global fine chemicals companies, |
| Merck KGaA 15 | | | | 2009 32 |
| Lanxess (Saltigo) 16 | | | | Table 3.3: BASF snapshot 40 |
| Sigma-Aldrich 16 | | | | Table 3.4: BASF financial performance by segment, |
| Jubilant Organosys 17 | | | | 2009 43 |
| Johnson Matthey 17 | | | | Table 3.5: BASF chemical sales performance, 2009 44 |
| Evonik Chemicals 18 | | | | Table 4.6: Lonza snapshot 48 |
| Chapter 1 Introduction 20 | | | | Table 4.7: Lonza financial performance by operating |
| What is this report about? 20 | | | | segments, 2009 51 |
| Methodology 20 | | | | Table 5.8: DSM snapshot 56 |
| Chapter 2 Industry overview 24 | | | | Table 5.9: DSM key launches in 2009 59 |
| Summary 24 | | | | Table 5.10: DSM R&D expenditure, 2009 59 |
| Fine chemicals – an overview 25 | | | | Table 5.11: DSM financial performance by segment, |
| Different types of fine chemicals 26 | | | | 2009 60 |
| Pharmaceutical intermediates 27 | | | | Table 5.12: DSM fine chemicals performance by |
| Agrochemical intermediates 28 | | | | segment, 2009 61 |
| Flavors and fragrances 28 | | | | Table 6.13: Sumitomo Chemical snapshot 64 |
| Dyes and others 29 | | | | Table 6.14: Sumitomo Chemical financial performance |
| Market dynamics 29 | | | | by operating segments, FY 2008 68 |
| Size and structure 29 | | | | Table 6.15: Sumitomo Chemical financial performance |
| Profitability 30 | | | | during FY 2004–2008 68 |
| Competitive landscape 30 | | | | Table 7.16: Merck KGaA Chemicals snapshot 74 |
| Manufacturing standards and their potential benefits 32 | | | | Table 7.17: Merck KGaA sales performance, 2009 77 |
| Potential benefits of the guideline 33 | | | | Table 7.18: Merck KGaA Chemicals segmentation |
| Key partnerships and M&A activity in the fine | | | | sales performance, 2009 77 |
| chemicals sector 34 | | | | Table 8.19: Lanxess (Saltigo) snapshot 82 |
| Key trends 35 | | | | Table 8.20: Lanxess financial performance by |
| Advanced technologies 35 | | | | operating segments, 2009 85 |
| Increasing demand for HPAPIs 35 | | | | Table 9.21: Sigma-Aldrich snapshot 90 |
| Relocation to emerging and fast growing markets 36 | | | | Table 9.22: Sigma-Aldrich financial performance by |
| Increasing use of biotechnology and nanotechnology | | | | operating segments, 2009 93 |
| 36 | | | | Table 10.23: Jubilant Organosys snapshot 99 |
| Chapter 3 BASF 40 | | | | Table 10.24: Jubilant Organosys financial performance |
| Summary 40 | | | | by operating segments, FY 2009 102 |
| Company overview 41 | | | | Table 10.25: Jubilant Organosys financial performance |
| Business segmentation 41 | | | | during FY 2005–2009 102 |
| R&D focus 42 | | | | Table 10.26: PLSPS revenue distribution by segments, |
| Financial performance 42 | | | | FY 2009 103 |
| Growth strategies 44 | | | | Table 10.27: CRAMS revenue distribution by segments, |
| Leading supplier of chemical intermediates 44 | | | | FY 2009 103 |
| Verbund, an innovative approach 44 | | | | Table 11.28: Johnson Matthey snapshot 108 |
| Diversified product portfolio 45 | | | | Table 11.29: Johnson Matthey financial performance by |
| SWOT analysis 45 | | | | operating segments, FY 2008 111 |
| Chapter 4 Lonza 48 | | | | Table 12.30: Evonik Industries snapshot 116 |
| Summary 48 | | | | Table 12.31: Evonik Industries financial performance by |
| Company overview 49 | | | | operating segments, 2009 118 |
| Business segmentation 49 | | | | Table 12.32: Evonik Chemicals financial performance by |
| R&D focus 50 | | | | segments, 2009 119 |
| Financial performance 51 | | | | Table 13.33: Boehringer Ingelheim snapshot 124 |
| Growth strategies 52 | | | | Table 13.34: Boehringer Ingelheim financial performance |
| Chemical manufacturing strengthens Lonza's | | | | by operating segments, 2009 125 |
| technology platform 52 | | | | Table 13.35: Divis Laboratories snapshot 125 |
| Partnership with biopharmaceutical and chemical | | | | Table 13.36: Divis Laboratories financial performance, |
| companies 52 | | | | FY 2008 126 |
| SWOT analysis 54 | | | | Table 13.37: Pfizer CentreSource snapshot 127 |
| Chapter 5 DSM 56 | | | | Table 13.38: Cambrex snapshot 128 |
| Summary 56 | | | | Table 13.39: Cambrex segmental revenue, 2009 129 |
| Company overview 57 | | | | Table 13. |